2026
Asymmetric One-Pot Total Synthesis of Tenuipesone A/B Through a Tunable Multienzyme Cascade
ChemistryEurope4, e202500440
Research
Three core technologies The toolkit behind our science — chemical catalysis, engineered biology, and the computational methods that connect them. Each feeds the others: catalysis defines the chemistry, engineered proteins and microbes run it, and machine learning steers the design–build–test loop.
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Technology · 01
Synthesis & catalysis
New synthetic methodology and catalysts — small-molecule, organo-, and biocatalytic — engineered to operate under mild, selective, biocompatible conditions, and assembled into one-pot cascades.
We invent new chemical reactions and the catalysts that drive them, designed to work gently enough to team up with living systems rather than fight them.
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Technology · 02
Protein engineering & designer microbes
Directed evolution and rational design of enzymes, deployed inside engineered microbial hosts — turning cells into programmable factories for complex, biomedically relevant molecules.
We redesign proteins to do new jobs and install them in microbes, turning living cells into tiny programmable factories that build useful molecules.
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Technology · 03
Artificial intelligence & machine learning
Machine-learning models for enzyme design, reaction prediction, and protein structure — accelerating the design–build–test cycle and steering experiments across every theme in the lab.
We use AI to predict how molecules and proteins will behave, so we can design smarter experiments faster instead of testing every possibility by hand.
Read more →Publications
Selected publications Recent work from the group. The full list also includes reviews, preprints, book chapters, and columns.
All publications →2026
Engineering Styrene Monooxygenases for Stereo-complementary Synthesis of Furoindolines and Pyranoindolines via Asymmetric Oxidative Dearomatization of Indol-3-yl Alcohols
ACS Catal.16, 11315–11323
2025
Asymmetric Ring Contraction of 2-Hydroxypyranones by Borrowing Hydrogen Biocatalysis
Chem. Sci.16, 17667–17674
2023
Aerobic C–N Bond Formation through Enzymatic Nitroso-Ene-Type Reactions
Angew. Chem. Int. Ed.62, e202213671
Partners
Funders & partners Our work is supported by national and European funding bodies, and conducted in collaboration with academic groups across Helsinki and beyond.
